With the financial and legal semi-autonomy, Khmer Soviet Friendship Hospital is headed by Professor NGY Meng, Director of the Hospital.
The Director is supervised by board members and assisted by eight Deputy Directors and a management team, three bureau and offices, follow by 25 medical departments, and other supportive departments.
The general policy of the institution is determined by the Board of Directors, made up of representatives of the Ministry of Health, Ministry of Economy and Finance, the Council of Ministers, the Municipality of Phnom Penh, the University of Health Sciences and staff of the hospital.